ABSTRACT NUMBER: ESOC2026A968 RISK OF EPILEPSY IN ELDERLY STROKE PATIENTS

Abstract Background and aims The incidence of epilepsy in elderly stroke patients has been significant attention because planning future needs for health services and improved primary and secondary prevention of stroke are important. We evaluated the relationship between stroke and the subsequent development of epilepsy within 10 years follow-up. Methods This retrospective, nationwide, longitudinal study used National Health Insurance Service –Senior cohort (NHIS-Senior) comprising 550,000 random subjects who were selected from over than 60 years old. This study included a cohort of 42,925 patients who were first diagnoses as stroke between 2019 and 2021. To match each stroke patient, 218,478 control subjects were selected from the data-base. Results In this cohort, the prevalence of stroke was higher in female(62%) than in male(38%). The diagnosis of epilepsy was done at averagely 20 months after the diagnosis of stroke. Cox regression analysis showed that the HR of epilepsy was 7.658 times greater for patients with stroke (95% CI: 7.402-7.923) than for control group after adjusting for other risk factors. The HR of epilepsy was 1.08 (95% CI: 1.045-1.116) in female patients, 1.66(95% CI: 1.607-1.715) in diabetic patients, 1.679(95% CI: 1.625-1.734) in hypertensive patients, 1.831(95% CI: 1.626-2.062) in chronic kidney disease and 1.647(95% CI: 1.593-1.703) in hypercholesterol patients. Conclusions Our findings suggest that stoke may be independent risk factor for epilepsy in elderly patients(HR 7.658, 95% CI: 7.402-7.923). So we need to control and pay attention to epilepsy in elderly stroke patients. Conflict of interest Jun Hong Lee: nothing to disclose