Magnesium as an Endocrine Modulator: Physiological Roles, Clinical Evidence, and Therapeutic Perspectives
CONTEXT: Magnesium deficiency is prevalent and increasingly recognized as an endocrine-relevant condition due to its involvement in hormone secretion, metabolic homeostasis, and cellular signaling. OBJECTIVE: To review current evidence on the role of magnesium in key endocrine systems and evaluate its clinical and therapeutic implications. EVIDENCE SYNTHESIS: Magnesium influences glucose metabolism, bone health, thyroid function, reproduction, cardiometabolic regulation, and HPA-axis activity. Clinical evidence shows strong associations between magnesium status and several endocrine diseases. CONCLUSION: Magnesium plays a multifaceted endocrine role with clinically significant implications. Improved diagnostic approaches and further interventional studies are warranted.
Authors
- Gaia Tabacco (ORCID: https://orcid.org/0000-0002-6808-0700)
- Anda Mihaela Naciu (ORCID: https://orcid.org/0000-0002-4576-3381)
- Cristiana Cipriani (ORCID: https://orcid.org/0000-0002-0141-1202)
- Ciro Menale (ORCID: https://orcid.org/0000-0001-5782-2089)
- Maria P. Yavropoulou (ORCID: https://orcid.org/0000-0002-6501-3692)
- Guido Zavatta (ORCID: https://orcid.org/0000-0003-3657-2070)
- Eleonora Sargentini
- Athanasios D Anastasilakis
- Andrea Palermo (ORCID: https://orcid.org/0000-0002-1143-4926)
Institutions
- Università Campus Bio-Medico (IT)
- National and Kapodistrian University of Athens (GR)
- San Raffaele University of Rome (IT)
- Azienda USL di Bologna (IT)
- 424 General Military Hospital (GR)
- Campus Bio Medico University Hospital (IT)
- University of Naples Federico II (IT)
- Sapienza University of Rome (IT)
- University of Bologna (IT)
Publication Details
- Journal
- European Journal of Endocrinology
- Published
- 2026-05-01
- DOI
- https://doi.org/10.1093/ejendo/lvag076
- Primary Topic
- Magnesium in Health and Disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00