Effects of apple cider vinegar on VEGF165 and glucose level in Diabetic Mellitus type-II patients

Background/Aims: The purpose of clinical trial to evaluate the effect of apple cider vinegar on VEGF165 and glucose level in type-II diabetes Mellitus (DM) patients. Methods: A clinical randomized trial with non-probability convenient sampling technique study was conducted on 110 eligible types-II diabetes Mellitus patients who were failed to control their glucose level and they were suggested for cataract (senile) surgery. 15-20 ml apple cider vinegar in 200 ml water before sleep at night for 6 months (follow-up after each 3 months). HbA1C, Fasting Blood Sugar, VEGF165 tests were performed Pre and Post operatively and analyzed using SPSS version 21. Result: Total 110 diabetic type-II patients who were (NPDR) in both eyes, high ration of age between 51-60 about 54.4%, females were 61.5% and majority were illiterate about 37.2%. about 58.2% patients strictly follow their medication, about 53.1% patients strictly follow their diet plane and about 48.2% patients strictly intake apple cider vinegar daily. Significant mean changes were found in VEGF165 (p<0.002), HbA1C (p<0.023), blood sugar fasting (p<0.012). Conclusion: Apple cider vinegar regularly is most effective in controlling diabetes and unusual production of VEGF165 (protein) of retina in DM type-II patient and control the worse condition of the eye moreover ophthalmologist can easily operate the cataract surgery and remove the dense cataract of the eye.