Environmental Factors Shape Terpenoid Accumulation and Predicted Bioactivity in <scp> <i>Houttuynia cordata</i> </scp>
. Transcriptomic analysis uncovered 103 differentially expressed genes in the MVA and MEP pathways, with several (e.g., AACT, FPPS, HMGR, DXS) showing strong correlations with core terpenoid accumulation. This multi-omics study provides insights into substantial geospatial variation in H. cordata terpenoids, identifies altitude and precipitation as major environmental factors associated with terpenoid accumulation, and offers a predictive framework for the biosynthetic network and multi-target pharmacological potential, especially anticancer. It offers a theoretical basis for quality control and optimized cultivation.
Authors
- Huiling Huang
- Yanping Mao
- Zhengqiao Liao
- Jie Yang (ORCID: https://orcid.org/0000-0003-4801-7162)
- Hongyi Liu (ORCID: https://orcid.org/0000-0002-8041-9789)
- Kai Hou (ORCID: https://orcid.org/0000-0001-7660-0393)
- Qian Wang
- Yangye Liao
- Lei Liu
Institutions
- Mianyang Normal University (CN)
- Sichuan Agricultural University (CN)
Publication Details
- Journal
- Physiologia Plantarum
- Published
- 2026-05-01
- DOI
- https://doi.org/10.1111/ppl.70911
- Primary Topic
- Nephrotoxicity and Medicinal Plants
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Department of Science and Technology of Sichuan Province