Real-world effectiveness of adjuvanted RSVPreF3 vaccine in preventing RSV-associated lower respiratory tract disease hospitalization in adults ≥60 years of age: early results from a test-negative design analysis
Abstract In a test-negative design, we estimated within-season vaccine effectiveness (VE) of adjuvanted RSVPreF3 against laboratory-confirmed respiratory syncytial virus (RSV)-lower respiratory tract disease-associated hospitalizations in adults ≥60 years during Dec2023–Feb2025. Results showed 82.3% overall VE and 81.0–92.1% VE across subgroups, including those at increased risk of severe RSV disease.
Authors
- David Singer (ORCID: https://orcid.org/0000-0001-8008-8003)
- Bradley K. Ackerson (ORCID: https://orcid.org/0000-0002-0816-7345)
- Nicolas Lecrenier (ORCID: https://orcid.org/0000-0002-0321-6283)
- Gina S. Lee (ORCID: https://orcid.org/0000-0002-7554-9116)
- Sijia Qiu (ORCID: https://orcid.org/0000-0002-4828-3180)
- Lina S. Sy (ORCID: https://orcid.org/0000-0003-2762-9266)
- Carolyn Hoke
- Andrew G. Allmon (ORCID: https://orcid.org/0009-0004-6879-9231)
- Cynthia Joe
- Jennifer H Ku (ORCID: https://orcid.org/0000-0001-9469-5875)
- Dominique Luyts (ORCID: https://orcid.org/0000-0001-8195-1526)
- Lauriane Harrington (ORCID: https://orcid.org/0000-0001-6765-8606)
- Lanfang Xu
- Elizabeth Marie Holdsworth La
- Punam P. Modha (ORCID: https://orcid.org/0009-0008-2274-1543)
- Hung-Fu Tseng
- Emily Rayens (ORCID: https://orcid.org/0000-0003-3369-3475)
- Britta I Amundsen (ORCID: https://orcid.org/0009-0007-6301-1611)
- Yi Luo (ORCID: https://orcid.org/0000-0001-8990-2470)
- Lei Qian (ORCID: https://orcid.org/0000-0001-8001-3992)
- Jean-Yves Pirçon (ORCID: https://orcid.org/0009-0003-1542-3292)
Institutions
- North Carolina Central University (US)
- Hawaii Department of Health (US)
- Kaiser Permanente (US)
- GlaxoSmithKline (Belgium) (BE)
- GlaxoSmithKline (United States) (US)
- Applied Optoelectronics (United States) (US)
- Hawaii Permanente Medical Group (US)
- New York Chiropractic College (US)
Publication Details
- Journal
- Open Forum Infectious Diseases
- Published
- 2026-05-01
- DOI
- https://doi.org/10.1093/ofid/ofag279
- Primary Topic
- Respiratory viral infections research
- Type
- article
- Field-Weighted Citation Impact
- 0.00