Precision Chemistry–Guided Peptide and Protein Self‐Assembly

ABSTRACT Peptides and proteins serve as versatile building blocks for advanced nano‐assemblies. Precision chemistry offers a new approach that applies site‐selective modification, sequence‐defined synthesis, and dynamic covalent design to direct molecular interactions at the atomic level. This concept examines how these tools enhance control over assembly kinetics and morphology, enabling the creation of “smart” stimuli‐responsive systems. These precision chemistry tools and techniques produce high‐performance nanostructures, such as protein cages and engineered networks, tailored for drug delivery, immunotherapy, and regenerative medicine. Convergence of molecular precision and AI‐driven predictive modeling is essential for the next generation of adaptive, multifunctional biomaterials.