Analysis of factors affecting lesion or HPV clearance rate after photodynamic therapy of persistent cervical intraepithelial neoplasia grade 1

OBJECTIVE: To investigate the potential influencing factors of photodynamic therapy (PDT) in patients with persistent cervical intraepithelial neoplasia grade 1 (CIN1), and to provide a basis for improving the therapeutic effect. METHODS: A retrospective study was conducted on patients with persistent CIN1 who had undergone PDT. Based on the reexamination results half a year after treatment, statistical analysis was performed on the human papillomavirus (HPV) clearance rate, histological regression rate, and the factors that might affect the therapeutic effect. RESULTS: In the multivariate analysis, normal cytological results before treatment were a positive influencing factor for post-treatment HPV clearance (P<0.05); HPV subtype 52/16 infection was a negative influencing factor for HPV clearance (P<0.05); and age ≥ 50 years was a negative influencing factor for the post-treatment histological regression rate (P<0.05). CONCLUSIONS: PDT can effectively treat persistent CIN1. However, histological regression is affected by the patient's age, and infection with HPV subtypes 52/16 tends to delay the conversion of HPV status to negative.