Lessons from Snakes: The Translational Potential of Extreme Physiological Adaptations in Cardiovascular Medicine

Snakes have evolved remarkable physiological regulatory mechanisms to withstand extreme challenges. From postprandial cardiac hypertrophy in pythons to gravity adaptation in arboreal species and hypoxia tolerance in high-altitude snakes, these evolutionary strategies offer valuable insights into the pathological mechanisms of human cardiovascular diseases and the development of novel therapeutic interventions.

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Publication Details

Journal
QJM
Published
2026-05-01
DOI
https://doi.org/10.1093/qjmed/hcag119
Primary Topic
Physiological and biochemical adaptations
Type
article
Field-Weighted Citation Impact
0.00
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article

Lessons from Snakes: The Translational Potential of Extreme Physiological Adaptations in Cardiovascular Medicine

Yihao Zhu, Lili Zhang
QJM
Physiological and biochemical adaptations
article

Lessons from Snakes: The Translational Potential of Extreme Physiological Adaptations in Cardiovascular Medicine

Yihao Zhu, Lili Zhang
article en

Abstract

Snakes have evolved remarkable physiological regulatory mechanisms to withstand extreme challenges. From postprandial cardiac hypertrophy in pythons to gravity adaptation in arboreal species and hypoxia tolerance in high-altitude snakes, these evolutionary strategies offer valuable insights into the pathological mechanisms of human cardiovascular diseases and the development of novel therapeutic interventions.

QJM
Naval Medical Research Command (US), Shanghai Sixth People's Hospital (CN)
Openalex Percentile: Top 6%
Physiological and biochemical adaptations
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