CHILD Syndrome without Limb Defects in a 1-year-old: revised nomenclature and successful treatment with Topical 2% Simvastatin/2% Cholesterol

The recent publication of a new gene-based classification for the ichthyoses has drawn attention to naming anomalies in other conditions. An example is CHILD syndrome (Congenital Ichthyosiform Erythroderma with Limb Defects) without Limb Defects, as reported here. We suggest nomenclature in line with the system used for the ichthyoses. We also report successful pathogenesis-based treatment in a very young child.

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Publication Details

Journal
Clinical and Experimental Dermatology
Published
2026-05-01
DOI
https://doi.org/10.1093/ced/llag193
Primary Topic
Genetic and rare skin diseases.
Type
article
Field-Weighted Citation Impact
0.00
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article

CHILD Syndrome without Limb Defects in a 1-year-old: revised nomenclature and successful treatment with Topical 2% Simvastatin/2% Cholesterol

Samantha Ibbs, Pratima Poudel, Joseph Wyer, Celia Moss
Clinical and Experimental Dermatology
Genetic and rare skin diseases.
article

CHILD Syndrome without Limb Defects in a 1-year-old: revised nomenclature and successful treatment with Topical 2% Simvastatin/2% Cholesterol

Samantha Ibbs, Pratima Poudel, Joseph Wyer, Celia Moss
article en

Abstract

The recent publication of a new gene-based classification for the ichthyoses has drawn attention to naming anomalies in other conditions. An example is CHILD syndrome (Congenital Ichthyosiform Erythroderma with Limb Defects) without Limb Defects, as reported here. We suggest nomenclature in line with the system used for the ichthyoses. We also report successful pathogenesis-based treatment in a very young child.

Clinical and Experimental Dermatology
Birmingham Women's Hospital (GB), Birmingham Children's Hospital (GB), Birmingham Women’s and Children’s NHS Foundation Trust (GB), University of Birmingham (GB)
Openalex Percentile: Top 7%
Genetic and rare skin diseases.
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CHILD Syndrome without Limb Defects in a 1-year-old: revised nomenclature and successful treatment with Topical 2% Simvastatin/2% Cholesterol — Samantha Ibbs, Pratima Poudel, et al. · Clinical and Experimental Dermatology (2026) | TGRS Research Map | TGRS