Tirzepatide-associated interstitial kidney injury

by 3 months). This case highlights a rare, biopsy-proven adverse renal effect of tirzepatide and underscores the importance of considering interstitial nephritis in patients with unexplained kidney injury on incretin mimetic therapy. Although glucagon-like peptide-1 receptor agonists benefits outweigh rare risks of nephrotoxicity, regular monitoring of creatinine monitoring is advised.

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Publication Details

Journal
JCEM Case Reports
Published
2026-04-10
DOI
https://doi.org/10.1210/jcemcr/luag125
Primary Topic
Nephrotoxicity and Medicinal Plants
Type
article
Field-Weighted Citation Impact
0.00
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article

Tirzepatide-associated interstitial kidney injury

Paloma Rodríguez Álvarez, Jagmeet Dhingra, Mohamed Eldib, Leila Zeinab Khan et al.
JCEM Case Reports
Nephrotoxicity and Medicinal Plants
article

Tirzepatide-associated interstitial kidney injury

Paloma Rodríguez Álvarez, Jagmeet Dhingra, Mohamed Eldib, Leila Zeinab Khan, Leal Herlitz, Vaidehi Mendpara
article en

Abstract

by 3 months). This case highlights a rare, biopsy-proven adverse renal effect of tirzepatide and underscores the importance of considering interstitial nephritis in patients with unexplained kidney injury on incretin mimetic therapy. Although glucagon-like peptide-1 receptor agonists benefits outweigh rare risks of nephrotoxicity, regular monitoring of creatinine monitoring is advised.

JCEM Case ReportsVol. 4(6)
Cleveland Clinic (US), Cleveland Foundation (US)
Good health and well-being
Openalex Percentile: Top 6%
Nephrotoxicity and Medicinal Plants
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