Tirzepatide-associated interstitial kidney injury
by 3 months). This case highlights a rare, biopsy-proven adverse renal effect of tirzepatide and underscores the importance of considering interstitial nephritis in patients with unexplained kidney injury on incretin mimetic therapy. Although glucagon-like peptide-1 receptor agonists benefits outweigh rare risks of nephrotoxicity, regular monitoring of creatinine monitoring is advised.
Authors
- Paloma Rodríguez Álvarez
- Jagmeet Dhingra
- Mohamed Eldib (ORCID: https://orcid.org/0009-0006-0783-5088)
- Leila Zeinab Khan
- Leal Herlitz
- Vaidehi Mendpara
Institutions
- Cleveland Clinic (US)
- Cleveland Foundation (US)
Publication Details
- Journal
- JCEM Case Reports
- Published
- 2026-04-10
- DOI
- https://doi.org/10.1210/jcemcr/luag125
- Primary Topic
- Nephrotoxicity and Medicinal Plants
- Type
- article
- Field-Weighted Citation Impact
- 0.00