Accumulated sotorasib-bound KRASG12C reactivates the MAPK pathway and drives sotorasib resistance via the DHX9-RAC1-PAK1 axis
-mutant and sotorasib-resistant models. These findings provide previously uncharacterized mechanistic insights to guide therapeutic strategies aimed at overcoming sotorasib resistance.
Authors
- Jielang Li (ORCID: https://orcid.org/0000-0003-3045-2668)
- Huanji Xu (ORCID: https://orcid.org/0000-0003-0314-5646)
- Chenliang Zhang (ORCID: https://orcid.org/0000-0003-2274-2657)
- Lijiao Pei
- Jue Li (ORCID: https://orcid.org/0000-0001-6546-5683)
- Feng Bi
- Gongmin Zhu
- Huixi Huang
- Qiulin Tang
- Di Ye
Institutions
- Sichuan University (CN)
- West China Hospital of Sichuan University (CN)
- Sichuan Cancer Hospital (CN)
Publication Details
- Journal
- Cell Reports
- Published
- 2026-05-01
- DOI
- https://doi.org/10.1016/j.celrep.2026.117338
- Primary Topic
- Protein Kinase Regulation and GTPase Signaling
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- Department of Science and Technology of Sichuan Province
- West China Hospital, Sichuan University