Multivalent nanoparticles activate T-dependent antibody response via antigen presentation by both B cells and dendritic cells
T cell proliferation. Moreover, B cell-mediated antigen presentation was required for inducing TD responses beyond the draining lymph nodes. These findings reveal a general mechanism by which multivalent nanoparticles engage B cells as APCs and highlight a potential strategy to enhance vaccine-induced immunity.
Authors
- Mingzhao Zhu (ORCID: https://orcid.org/0000-0003-2001-2669)
- Zhaolin Hua (ORCID: https://orcid.org/0000-0001-9242-1387)
- Keyan Bao (ORCID: https://orcid.org/0000-0002-1777-7006)
- Runhan Li (ORCID: https://orcid.org/0000-0002-8279-4750)
- Zhiyu Gao (ORCID: https://orcid.org/0009-0006-8496-8669)
- Xueli Zhang (ORCID: https://orcid.org/0000-0002-8660-4037)
- George F. Gao
- Penghui Ma
- Chang Guo
- Xuejing Ma
- Baidong Hou (ORCID: https://orcid.org/0000-0002-0892-0181)
- Han Wang
- Ping Zhu
- Wenjun Wang
Institutions
- Chinese Academy of Sciences (CN)
- Peking University (CN)
- Institute of Biophysics (CN)
- Sino-Danish Centre for Education and Research (CN)
- Institute of Microbiology (CN)
- University of Chinese Academy of Sciences (CN)
Publication Details
- Journal
- Cell Reports
- Published
- 2026-05-01
- DOI
- https://doi.org/10.1016/j.celrep.2026.117332
- Primary Topic
- Immunotherapy and Immune Responses
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Chinese Academy of Sciences
- Ministry of Science and Technology of the People's Republic of China