Exploring Non-starch Polysaccharides as Therapeutic Interventions in Intestinal Inflammation Mediated by Neurological Conditions

Introduction: The Gut-brain axis is a newly explored bidirectional channel that controls several neurological and intestinal disorders. There is evidence that several gastrointestinal inflammatory diseases are regulated by changes in neurological processes. Gut-brain axismediated intestinal inflammation represents a chronic and often progressive condition, affecting a significant portion of the global population. Methods: Scientific literature was retrieved from PubMed, Scopus, Web of Science, and Google Scholar databases covering publications from 2000 to 2025. Result: The findings of this article also underscore multiple lines of evidence focusing on the application of non-starch polysaccharides in the prevention of Alzheimer’s disease. Discussion: Intestinal inflammation is characterized by persistent symptoms including diarrhoea, rectal bleeding, and abdominal pain. However, several therapeutic substances are available to mitigate these symptoms, yet none of them provide effective and long-lasting solutions. Several reports have suggested that the dysbiosis condition and further associated comorbidities may be reversed by including some minor changes in our daily lifestyles. These changes include controlling stress, meditation, exercise, and, more importantly, our diet. The literature indicates that the inclusion of non-starch polysaccharides in the diet may help in both ways (therapeutic and prophylactic) to mitigate the disease. Unlike other polysaccharides, non-starch polysaccharides remain undigested and reach the colon successfully, which helps in the healing of damaged gut epithelia by increasing the expression of healing proteins and immune cells. Conclusion: In this context, this review article summarizes several biological pathways in which non-starch polysaccharides play an important role in controlling the disease progression and promoting healing.