Efficacy and Safety of a Defined Two‐Dose Protocol of Autologous Platelet‐Rich Plasma ( <scp>PRP</scp> ) Injection for Refractory Chronic Non‐Healing Wounds: A Prospective Clinical Study
. Three patients (16.67%) achieved complete epithelialization. Subgroup trends suggested diabetic and venous ulcers responded more favourably than radiation-induced ulcers. The protocol was safe, with no systemic or severe localized adverse events observed among participants. The defined two-dose PRP injection protocol provides a clinically effective and safe adjunctive therapy that significantly promotes wound area reduction in challenging chronic non-healing wounds. This reproducible, low-frequency protocol offers a rationale for standardization in advanced wound care, warranting validation through future large-scale Randomized Controlled Trials (RCTs).
Authors
- Kriangsak Jenwitheesuk (ORCID: https://orcid.org/0000-0001-7353-5397)
- Weerin Sawangkajohn
- Kengkart Winaikosol (ORCID: https://orcid.org/0000-0002-8348-5941)
- Wiyada Punjaruk (ORCID: https://orcid.org/0000-0002-8570-1302)
- Kamonwan Jenwitheesuk (ORCID: https://orcid.org/0000-0002-2651-5753)
- Kaweesak Saothonglang
- Thitinan Kasetthat
- Palakorn Surakunprapha (ORCID: https://orcid.org/0000-0001-5732-6720)
- Pimthawan Vachirodom
- Pattama Punyawong
- Nathathai Wanchutrirat
Institutions
- Khon Kaen University (TH)
Publication Details
- Journal
- International Wound Journal
- Published
- 2026-05-01
- DOI
- https://doi.org/10.1111/iwj.70932
- Primary Topic
- Periodontal Regeneration and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Khon Kaen University