Expanding Threat of Carbapenemase-Producing <i>Escherichia coli</i> and <i>Klebsiella pneumoniae</i> in Peru: Genomic and Phenotypic Evidence of High-Risk Clones Dissemination
, indicating sustained local dissemination of high-risk clonal groups. The coexistence of multiple carbapenemases and plasmid backbones highlights the ongoing evolution of resistance mechanisms. These findings provide actionable evidence to guide treatment strategies in settings with high prevalence of metallo-β-lactamases and underscores the need for continuous genomic surveillance and antimicrobial stewardship to mitigate their clinical and epidemiological impact.
Authors
- Elizabeth Sierra (ORCID: https://orcid.org/0000-0003-1940-4702)
- Edgar Gonzáles-Escalante (ORCID: https://orcid.org/0000-0002-3411-9021)
- Giancarlo Perez
- Liliana Morales
- José da Matta
- Arturo Gonzales-Rodriguez (ORCID: https://orcid.org/0000-0002-6377-1596)
- Rocky Champi (ORCID: https://orcid.org/0000-0002-5275-4643)
- Roxana Sandoval
- Luis Alvarado (ORCID: https://orcid.org/0000-0003-2677-7179)
- Janet Canseco
- Juan Carlos Gómez-de-la-Torre (ORCID: https://orcid.org/0000-0003-4566-2027)
- Alejandra Escobar
Institutions
- University of Piura (PE)
- Hospital Nacional Cayetano Heredia (PE)
- Forum Solidaridad Perú (PE)
- Hospital Base Guillermo Almenara Irigoyen (PE)
Publication Details
- Journal
- bioRxiv (Cold Spring Harbor Laboratory)
- Published
- 2026-05-01
- DOI
- https://doi.org/10.64898/2026.04.28.721358
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 0.00