Spatial Single-Cell Proteomics Reveals Molecular Trajectories Of Tangle-Bearing Neurons In Alzheimer’s Disease
and define a continuum of neuronal states underlying tau pathogenesis, revealing early vulnerabilities and adaptive responses during AD progression.
Authors
- Martha Foiani (ORCID: https://orcid.org/0000-0003-4157-2606)
- Mathieu Bourdenx (ORCID: https://orcid.org/0000-0002-9799-9222)
- Damoc S Luiza
- Kraller Lukas (ORCID: https://orcid.org/0009-0006-9785-3596)
- Jaunmuktane Zane (ORCID: https://orcid.org/0000-0001-7738-8881)
- Patel Saisha
- Coscia Fabian (ORCID: https://orcid.org/0000-0002-2244-5081)
- Yiu Angela
- Davies Hannah
- Nirujogi S Raja (ORCID: https://orcid.org/0000-0002-3177-8566)
- Duff E Karen (ORCID: https://orcid.org/0000-0002-6177-868X)
- Mitchener Ludovico
Institutions
- University of Dundee (GB)
- German Cancer Research Center (DE)
- Neurosciences Institute (US)
- Max Delbrück Center (DE)
- MRC Protein Phosphorylation and Ubiquitylation Unit (GB)
- Institute for Scientific Analysis (US)
- UK Dementia Research Institute (GB)
- National Hospital for Neurology and Neurosurgery (GB)
- Deutsches Konsortium für Translationale Krebsforschung (DE)
- University College London (GB)
- Freie Universität Berlin (DE)
Publication Details
- Journal
- bioRxiv (Cold Spring Harbor Laboratory)
- Published
- 2026-04-29
- DOI
- https://doi.org/10.64898/2026.04.26.720932
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Alzheimer’s Research UK
- UK Dementia Research Institute