Fe3+-based nanovesicle mediated transferrin hijacking for glioblastoma stem cell tumoricidal treatment and postoperative recurrence inhibition
released from hemoglobin in RNVs to create a feedback loop that amplifies ferroptosis effects, enhancing the chemotherapeutic efficacy of temozolomide against GSCs. This Tf-hijacking nanovesicle enables GSC tumoricidal treatment and provides a novel approach for GBM postoperative recurrence inhibition.
Authors
- Weiling Zhuo
- Fuming Liang (ORCID: https://orcid.org/0009-0009-6511-028X)
- Wanyu Wang
- Hongxu Chen
- Xia Liu
- Xiang Xiang Wang (ORCID: https://orcid.org/0000-0002-8978-2453)
- Jianguo Xu
- Xiang Yu Gao (ORCID: https://orcid.org/0000-0002-6108-2551)
Institutions
- Sichuan University (CN)
- State Key Laboratory of Biotherapy
Publication Details
- Journal
- Bioactive Materials
- Published
- 2026-05-01
- DOI
- https://doi.org/10.1016/j.bioactmat.2026.04.014
- Primary Topic
- Nanoparticle-Based Drug Delivery
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Sichuan Province Science and Technology Support Program
- National Key Research and Development Program of China
- National Key Research and Development Program of China Stem Cell and Translational Research