The physiological roles of primary ciliary resorption and its potential as therapeutic targets

/S phases of the cell cycle. Additionally, we found that phospho-(T94)Tctex-1 localizes to the ciliary transition zone of neural progenitor cells in the fetal cerebral cortex, where it regulates cell cycle reentry and neurogenesis. Recent reports indicate that mice with abnormal ciliary resorption develop microcephaly-like symptoms. Our study and these reports shed light on the physiological significance of ciliary resorption. Finally, this review discusses new directions in ciliary resorption research and its potential therapeutic applications.

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Publication Details

Journal
Folia Pharmacologica Japonica
Published
2026-04-30
DOI
https://doi.org/10.1254/fpj.26013
Primary Topic
Genetic and Kidney Cyst Diseases
Type
article
Field-Weighted Citation Impact
0.00
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article

The physiological roles of primary ciliary resorption and its potential as therapeutic targets

Gen-ichi Atsumi, Masaki Saito
Folia Pharmacologica Japonica
Genetic and Kidney Cyst Diseases
article

The physiological roles of primary ciliary resorption and its potential as therapeutic targets

Gen-ichi Atsumi, Masaki Saito
article en

Abstract

/S phases of the cell cycle. Additionally, we found that phospho-(T94)Tctex-1 localizes to the ciliary transition zone of neural progenitor cells in the fetal cerebral cortex, where it regulates cell cycle reentry and neurogenesis. Recent reports indicate that mice with abnormal ciliary resorption develop microcephaly-like symptoms. Our study and these reports shed light on the physiological significance of ciliary resorption. Finally, this review discusses new directions in ciliary resorption research and its potential therapeutic applications.

Folia Pharmacologica JaponicaVol. 161(3)
Teikyo University (JP)
Zero hunger
Openalex Percentile: Top 8%
Genetic and Kidney Cyst Diseases
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