The physiological roles of primary ciliary resorption and its potential as therapeutic targets
/S phases of the cell cycle. Additionally, we found that phospho-(T94)Tctex-1 localizes to the ciliary transition zone of neural progenitor cells in the fetal cerebral cortex, where it regulates cell cycle reentry and neurogenesis. Recent reports indicate that mice with abnormal ciliary resorption develop microcephaly-like symptoms. Our study and these reports shed light on the physiological significance of ciliary resorption. Finally, this review discusses new directions in ciliary resorption research and its potential therapeutic applications.
Authors
- Gen-ichi Atsumi
- Masaki Saito
Institutions
- Teikyo University (JP)
Publication Details
- Journal
- Folia Pharmacologica Japonica
- Published
- 2026-04-30
- DOI
- https://doi.org/10.1254/fpj.26013
- Primary Topic
- Genetic and Kidney Cyst Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00