The Serum Platelet-Albumin Ratio in Hyperemesis Gravidarum: A Retrospective Comparative Study

Purpose: This study aimed to evaluate the association between platelet-to-albumin ratio (PAR) and hyperemesis gravidarum (HG), and to assess its potential diagnostic value. Patients and Methods: This retrospective comparative study was conducted at a tertiary obstetrics center between January 2024 and December 2025. A total of 160 pregnant women were included (80 with HG and 80 healthy controls). Demographic, clinical, and laboratory parameters were analyzed. Results: Gravidity and parity differed significantly between groups (p<0.001). Among laboratory parameters, TSH (1.64±0.53 vs 1.20±0.39, p=0.006), potassium (4.06±0.41 vs 3.95±0.43, p=0.003), albumin (42.69±5.72 vs 39.59±8.56, p<0.001), and PAR (6.15±1.49 vs 9.26±2.89, p<0.001) were significantly different. ROC analysis demonstrated that PAR had a cut-off value of ≥6.51 for predicting HG (AUC = 0.825, 95% CI: 0.74-0.88), with 82.1% sensitivity and 66.2% specificity. The positive predictive value (PPV) was 80.9% and the negative predictive value (NPV) was 79.1%. Conclusion: PAR levels were significantly elevated in patients with HG and may serve as a simple and accessible biomarker. However, larger prospective studies are required to validate these findings.