Mutation of a single cysteine in CaMKIIδ protects the heart from ischemia-reperfusion Injury
mouse had improved cardiac function and decreased infarct size compared to the wild-type mouse. We conclude that blocking disulfide formation at Cys273 protects the heart against ischemia-reperfusion injury. Drugs that specifically target Cys 273 may be therapeutic in human cardiac disease.
Authors
- Junhui Sun (ORCID: https://orcid.org/0000-0002-1816-1190)
- Nathália Rocco Machado
- Elizabeth Murphy
- Audrey Noguchi
- Danielle Springer
- Rodney Levine
- Chengyu Liu
Institutions
- National Heart, Lung, and Blood Institute (US)
Publication Details
- Journal
- bioRxiv (Cold Spring Harbor Laboratory)
- Published
- 2026-04-30
- DOI
- https://doi.org/10.64898/2026.04.27.721066
- Primary Topic
- Endoplasmic Reticulum Stress and Disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00