Does a low-carbohydrate diet impede endurance sports performance? No

max. Indeed, during the 6 × 800 m interval repetition session, some subjects achieved the highest rates of fat oxidation (2 g/min) ever reported in humans; whereas ingestion of 10 g carbohydrate/h improved prolonged cycling test performance by 22%, equally following either diet. These data establish that muscle glycogen is not an obligatory fuel for exercise. Rather, exercise-induced hypoglycemia due to depletion of glucose in the small glucose pool in the liver and bloodstream, prevented by minimal carbohydrate ingestion during exercise, is the main metabolic contributor to premature fatigue during more prolonged submaximal exercise.

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Publication Details

Journal
American Journal of Clinical Nutrition
Published
2026-05-01
DOI
https://doi.org/10.1016/j.ajcnut.2026.101269
Primary Topic
Muscle metabolism and nutrition
Type
article
Field-Weighted Citation Impact
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article

Does a low-carbohydrate diet impede endurance sports performance? No

T Noakes, Louise M Burke
American Journal of Clinical Nutrition
Muscle metabolism and nutrition
article

Does a low-carbohydrate diet impede endurance sports performance? No

T Noakes, Louise M Burke
article en

Abstract

max. Indeed, during the 6 × 800 m interval repetition session, some subjects achieved the highest rates of fat oxidation (2 g/min) ever reported in humans; whereas ingestion of 10 g carbohydrate/h improved prolonged cycling test performance by 22%, equally following either diet. These data establish that muscle glycogen is not an obligatory fuel for exercise. Rather, exercise-induced hypoglycemia due to depletion of glucose in the small glucose pool in the liver and bloodstream, prevented by minimal carbohydrate ingestion during exercise, is the main metabolic contributor to premature fatigue during more prolonged submaximal exercise.

American Journal of Clinical NutritionVol. 123(5)
University of Cape Town (ZA), Australian Catholic University (AU)
Openalex Percentile: Top 8%
Muscle metabolism and nutrition
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