Synchronous squamous cell carcinomas of the glans penis and scrotum: A case report and literature review

Squamous cell carcinomas (SCCs) of the male external genitalia are uncommon malignancies, with scrotal SCC being particularly rare. The synchronous occurrence of SCC involving both the glans penis and the scrotum represents an exceptional clinical entity with limited documentation in the published literature. We report the case of a 70-year-old uncircumcised man with a background of HIV infection on antiretroviral therapy and remote tobacco use, who presented with a rare synchronous dual-site genital SCC. The pathophysiological, diagnostic, and therapeutic implications of this presentation are discussed in light of current evidence.