Pneumococcal Vaccination Series Completion Among Eligible Pregnant Individuals [ID 3390]

INTRODUCTION: Streptococcus pneumoniae is a leading cause of pneumonia, meningitis, and invasive disease, with certain conditions causing a higher risk of disease. The American College of Obstetricians & Gynecologists recommends S pneumoniae vaccination during pregnancy for high-risk individuals. No prior studies have examined pneumococcal vaccination rates during pregnancy. We aimed to determine pneumococcal vaccination rates among eligible pregnant individuals before and during pregnancy. Secondary aims included identifying factors associated with pneumococcal vaccination during pregnancy and series completion. METHODS: We conducted a retrospective observational cohort study of pneumococcal vaccine–eligible pregnant individuals who delivered at our institution between January and December 2024. Summary and descriptive statistics were used to describe demographic information, clinical history, and pneumococcal vaccination history. Bivariate analysis compared vaccination during pregnancy versus not, and up-to-date versus not. Logistic regression analysis determined factors associated with pneumococcal vaccination being up to date. RESULTS: Four hundred ninety-two participants were included. Fifty-four percent of participants were Black, 24% were White, and 13% were Hispanic. Qualifying medical conditions included asthma (72.2%), tobacco use (18.5%), and preexisting diabetes (10.3%). One percent received vaccination during pregnancy, and 7.7% were up to date on vaccination. Participants with HIV received vaccination less often during pregnancy (2% versus 20%, P =.004). Preexisting diabetes was associated with three times higher odds of vaccination being up to date (adjusted odds ratio 2.766; 95% CI, 1.208–6.329). CONCLUSIONS/IMPLICATIONS: This is the first study to evaluate pneumococcal vaccination during pregnancy. Pneumococcal vaccination rates during pregnancy were low at only 1%. Increasing provider awareness and vaccine access may help raise rates among eligible pregnant individuals.