Phantom- and simulation-based validation of combined diffusion relaxometry in ex vivo ADRD white matter
Purpose: -D for ex vivo analysis of WM lesions in ADRD tissue. Methods: , slow diffusion). Results: 25 ms. Conclusion: , restricted-D components are therefore unlikely to be artifacts and instead support interpretations as physically meaningful myelin and axonal water signatures.
Authors
- Andrea Jacobson
- Navid Seraji‐Bozorgzad (ORCID: https://orcid.org/0000-0002-8215-6513)
- Jeffrey A. Fessler (ORCID: https://orcid.org/0000-0001-9998-3315)
- Amaya M Murguia (ORCID: https://orcid.org/0009-0004-5546-1274)
- Scott D. Swanson (ORCID: https://orcid.org/0000-0002-4714-4031)
- Jon-Fredrik Nielsen (ORCID: https://orcid.org/0000-0002-2058-3579)
Institutions
- University of Michigan (US)
- Michigan Medicine (US)
Publication Details
- Journal
- bioRxiv (Cold Spring Harbor Laboratory)
- Published
- 2026-04-30
- DOI
- https://doi.org/10.64898/2026.04.27.721146
- Primary Topic
- Advanced Neuroimaging Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health