NOP2-mediated 5-methylcytosine Regulates Lipid Metabolism Reprogramming to Prime Tumors for Ferroptosis in Bladder Cancer Progression
C methyltransferase NOP2 in BCa and reveal a novel NOP2/YBX1/SCD axis that links epitranscriptomic regulation, metabolic reprogramming and ferroptosis evasion, providing a new target for therapeutic intervention.
Authors
- Guanghou Fu (ORCID: https://orcid.org/0000-0003-4243-3894)
- Jianguo Gao
- Yunfei Wu
- Runzhe Wang
- Yupeng Wang
- Baiye Jin
- Cheng Cheng
Institutions
- Huzhou Normal University (CN)
- Zhejiang University (CN)
Publication Details
- Journal
- International Journal of Biological Sciences
- Published
- 2026-04-16
- DOI
- https://doi.org/10.7150/ijbs.126325
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Science and Technology Program of Zhejiang Province