Transcatheter Folded Valve Placement Within a Patent Ductus Arteriosus for Pulmonary Hypertension

BACKGROUND: Severe pulmonary arterial hypertension (PAH) with bidirectional patent ductus arteriosus (PDA) presents a challenge, as ductal closure is contraindicated. CASE SUMMARY: A 14-year-old boy with severe PAH and bidirectional PDA experienced exercise intolerance. He underwent transcatheter placement of a 20-mm folded Melody valve within the native PDA. The procedure eliminated diastolic left-to-right shunting while preserving systolic right-to-left shunting. At 1-year follow-up, he demonstrated durable unidirectional shunting and improved to NYHA functional class I status. DISCUSSION: While surgical valved reverse Potts shunts exist in the literature, adapting a transcatheter valve to create a unidirectional shunt within the native PDA percutaneously is novel. It offers a less invasive alternative for managing suprasystemic PAH. TAKE-HOME MESSAGES: Transcatheter folded valve placement within a native PDA safely establishes a unidirectional right-to-left shunt. This intervention reduces pulmonary overcirculation while maintaining vital ventricular decompression.

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Publication Details

Journal
JACC Case Reports
Published
2026-05-01
DOI
https://doi.org/10.1016/j.jaccas.2026.108137
Primary Topic
Cardiovascular Conditions and Treatments
Type
article
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article

Transcatheter Folded Valve Placement Within a Patent Ductus Arteriosus for Pulmonary Hypertension

Eli S. Fredman, Hadeel Allam, Nidhy P. Varghese, R. Mark Grady et al.
JACC Case Reports
Cardiovascular Conditions and Treatments
article

Transcatheter Folded Valve Placement Within a Patent Ductus Arteriosus for Pulmonary Hypertension

Eli S. Fredman, Hadeel Allam, Nidhy P. Varghese, R. Mark Grady, Manish Aggarwal, Daisuke Kobayashi, David Balzer
article en

Abstract

BACKGROUND: Severe pulmonary arterial hypertension (PAH) with bidirectional patent ductus arteriosus (PDA) presents a challenge, as ductal closure is contraindicated. CASE SUMMARY: A 14-year-old boy with severe PAH and bidirectional PDA experienced exercise intolerance. He underwent transcatheter placement of a 20-mm folded Melody valve within the native PDA. The procedure eliminated diastolic left-to-right shunting while preserving systolic right-to-left shunting. At 1-year follow-up, he demonstrated durable unidirectional shunting and improved to NYHA functional class I status. DISCUSSION: While surgical valved reverse Potts shunts exist in the literature, adapting a transcatheter valve to create a unidirectional shunt within the native PDA percutaneously is novel. It offers a less invasive alternative for managing suprasystemic PAH. TAKE-HOME MESSAGES: Transcatheter folded valve placement within a native PDA safely establishes a unidirectional right-to-left shunt. This intervention reduces pulmonary overcirculation while maintaining vital ventricular decompression.

JACC Case Reports
St. Louis Children's Hospital (US), Texas Children's Hospital (US)
Good health and well-being
Openalex Percentile: Top 7%
Cardiovascular Conditions and Treatments
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