A MAM-targeting therapeutic peptide restores autophagy homeostasis and ameliorates atherosclerosis

Rationale: R-GRP75-VDAC1 complex and evaluate its therapeutic efficacy in atherosclerosis. Methods: mice. Results: mice. Conclusions: R-GRP75 interaction as a promising strategy to modulate MAM structure, activate adaptive autophagy, and alleviate atherosclerotic pathology. This study supports organelle contact site modulation as both a therapeutic mechanism and a measurable disease-responsive feature, highlighting peptide-based modulation of protein-protein interactions as a promising approach for metabolic and cardiovascular diseases.