Multiscale design of core-shell GelMA-alginate composite microspheres enabling spatially compartmentalized co-culture of skin cells

, while high-yield fabrication demonstrates the scalability of the coaxial electrospray approach. Collectively, this work establishes spatial compartmentalization as a multiscale design principle for enabling spatially regulated heterotypic cell interactions, preventing fibroblast overgrowth and enabling modular, directly deployable multicellular platforms for spatially controlled skin cell delivery and tissue engineering.