Distribution and Antibiotic Resistance Characteristics of Pathogenic Bacteria in Chronic Wound Infections: A Five-Year Retrospective Study at a Tertiary Hospital

Objective: This study aimed to characterize the microbial profiles and antibiotic resistance patterns of predominant pathogens in chronic wounds, with the ultimate goal of optimizing evidence-based antimicrobial therapy to improve wound healing outcomes. Methods: Clinical data and microbial specimens (wound secretions, blood and urine) were collected from patients admitted to the Burns Department of the Second Affiliated Hospital of Kunming Medical University (January 2019-December 2023). Bacterial identification and antibiotic susceptibility testing were performed via standard microbiological methods and interpreted per CLSI guidelines. Statistical analyses were conducted via SPSS 27.0 and WHONET 5.6. Results: < 0.05). Conclusion: is the most prevalent pathogen in chronic wounds, and the presence of multidrug-resistant bacteria complicates treatment, increasing resistance to empiric antibiotics. Tailored antimicrobial therapy on the basis of local resistance patterns is critical for effective management.