Principles for the design of multispecific proteins
Multispecificity involves high-affinity binding to multiple related ligands while preserving discrimination against other ligands. The binding of tick evasins to human CC chemokines exemplifies key principles of multispecific binding: a rigid core recognising conserved features of all targets, with flexible peripheral regions enabling discrimination within the target family.
Authors
- Ram Prasad Bhusal (ORCID: https://orcid.org/0000-0002-2997-3995)
- Martin J. Stone (ORCID: https://orcid.org/0000-0002-6468-4427)
- Shankar Raj Devkota (ORCID: https://orcid.org/0000-0002-3154-7928)
- Pramod Aryal
- Surendra Kunwar
- Mikaela Bell
Institutions
- Discovery Institute (US)
- Monash University (AU)
- The University of Adelaide (AU)
Publication Details
- Journal
- Trends in Biochemical Sciences
- Published
- 2026-05-01
- DOI
- https://doi.org/10.1016/j.tibs.2026.04.007
- Primary Topic
- Chemokine receptors and signaling
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Health and Medical Research Council