A bifidobacterial enzyme orchestrates ecology and function of infant gut bacterial community
genomes. Together, we demonstrated that a single enzyme-substrate interaction could orchestrate the composition and metabolic function of an infant bacterial community, which may contribute to the assembly of dynamic infant gut microbiota. Our integrative approach provides a mechanistic framework for understanding the interaction between diet, microbial community, and infant gut health.
Authors
- Gertjan Kramer (ORCID: https://orcid.org/0000-0002-8541-0337)
- Yangwei Shan (ORCID: https://orcid.org/0000-0001-6902-552X)
- W. Du (ORCID: https://orcid.org/0000-0003-3484-4298)
- Meike T. Wortel (ORCID: https://orcid.org/0000-0002-3191-2710)
- Shijia Li (ORCID: https://orcid.org/0000-0002-8813-7815)
- Nicholas Pucci
- Aalt Dirk Jan van Dijk
- Jianbo Zhang (ORCID: https://orcid.org/0000-0003-3526-4586)
- Alejandro Sanchez-Cano
- Myrthe Beijnvoort
- Coen Berns (ORCID: https://orcid.org/0000-0002-9675-9083)
- Rick Hoogendijk
- Daniel R. Mende (ORCID: https://orcid.org/0000-0001-6831-4557)
Institutions
- Netherlands Institute for Neuroscience (NL)
- Keio University (JP)
- Amsterdam University Medical Centers (NL)
- Amsterdam University of Applied Sciences (NL)
- University of Amsterdam (NL)
Publication Details
- Journal
- bioRxiv (Cold Spring Harbor Laboratory)
- Published
- 2026-04-29
- DOI
- https://doi.org/10.64898/2026.04.28.718440
- Primary Topic
- Infant Nutrition and Health
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek