Elevated target expression by dual PD-L1 and 4-1BB engagement is associated with <sup>89</sup> Zr-PD-L1x4-1BB bispecific Mabcalin tumor uptake
The biodistribution of mPD-L1xh4-1BB is specific, dose-dependent, and associated with the elevated target expression resulting from dual PD-L1 and 4-1BB engagement.
Authors
- C. Winkel
- Aizea Morales‐Kastresana (ORCID: https://orcid.org/0000-0003-1401-9805)
- Agathe Lepissier
- Wim Timens (ORCID: https://orcid.org/0000-0002-4146-6363)
- Glenn Gauderat
- Lucia Pattarini
- Nicole Andersen
- Marleen Richter
- Helene Lelievre
- Thomas Jaquin
- Elisabeth G.E. de Vries
- Steven de Jong
- Laurent Laboureur
- Xiaoyu Fan
- Stefan Grüner
- Marjolijn N. Lub-de Hooge
- Danique Giesen
Institutions
- University Medical Center Groningen (NL)
- Pieris Pharmaceuticals (United States) (US)
- CEA Paris-Saclay (FR)
Publication Details
- Journal
- Theranostics
- Published
- 2026-04-22
- DOI
- https://doi.org/10.7150/thno.123930
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.00