Mitophagy-activating nanozyme hydrogel for enhanced diabetic wound healing
, topical application of Se-CDs@Gelatin-TA hydrogel accelerated wound closure, reduced inflammatory infiltration, enhanced collagen deposition, and restored endogenous antioxidant enzyme activity in wound tissues. This work presents a novel nanozyme-based targeted strategy for diabetic wounds, leveraging Se-CDs to modulate mitophagy and redox homeostasis, and provides mechanistic insights into the role of PINK1/Parkin-mediated mitophagy in diabetic wound repair.
Authors
- Xuanfen Zhang (ORCID: https://orcid.org/0000-0002-0352-1528)
- Zhenshuai Tang
- Hao Zhang (ORCID: https://orcid.org/0009-0008-9285-5028)
- Jia Zhang
- Weiwei He (ORCID: https://orcid.org/0000-0002-3495-9514)
Institutions
- Lanzhou University Second Hospital (CN)
- Dynamic Systems (United States) (US)
- Lanzhou University (CN)
- Xuchang University (CN)
Publication Details
- Journal
- Materials Today Bio
- Published
- 2026-05-01
- DOI
- https://doi.org/10.1016/j.mtbio.2026.103173
- Primary Topic
- Nanoplatforms for cancer theranostics
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China