Rejuvenating the blood: a new intervention targeting RhoA nuclear mechanoactivity in aged haematopoietic stem cells

Rejuvenating the blood: a new intervention targeting RhoA nuclear mechanoactivity in aged haematopoietic stem cells Elderly cancer patients suffer high haematopoietic toxicity upon chemotherapy. ReSinAge aims to boost haematopoietic recovery and increase the survival after chemotherapy in the elderly by improving the regenerative capacity of the aged haematopoietic stem cell niche. In detail, we aim to disclose the functional interplay between blood stem cells and their niche, and its targeting as an innovative strategy to overcome chemotherapy toxicity and increase the survival of elderly cancer patients.