Solvent‐Dependent Biological Activities of Aqueous and Ethanolic Extracts From Edible Insect Larvae

(AD) were evaluated using multiple in vitro models. The aqueous extracts of AD and PBS exhibited strong antioxidant activity in HepG2 hepatocytes and human dermal fibroblast (HDF) cells. Most extracts suppressed nitric oxide production in lipopolysaccharide-stimulated RAW 264.7 macrophages, indicating anti-inflammatory effects. In addition, all larval extracts inhibited β-hexosaminidase release in IgE/BSA-stimulated mast cells, suggesting anti-allergic potential. The protein-rich aqueous and ethanolic extracts showed relatively stronger angiotensin-converting enzyme (ACE) inhibitory activity, whereas polyphenol-rich ethanolic extracts more effectively reduced lipid accumulation in differentiated 3T3-L1 adipocytes. These findings highlight solvent-dependent functional activity profiles of edible insect larval extracts and support their potential as sustainable sources of bioactive ingredients.

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Publication Details

Journal
Food Science & Nutrition
Published
2026-05-01
DOI
https://doi.org/10.1002/fsn3.71848
Primary Topic
Insect Utilization and Effects
Type
article
Field-Weighted Citation Impact
0.00

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article

Solvent‐Dependent Biological Activities of Aqueous and Ethanolic Extracts From Edible Insect Larvae

Ginnae Ahn, Eui Jeong Han, Hae In Yong, Seung Tae Im et al.
Food Science & Nutrition
Insect Utilization and Effects
article

Solvent‐Dependent Biological Activities of Aqueous and Ethanolic Extracts From Edible Insect Larvae

Ginnae Ahn, Eui Jeong Han, Hae In Yong, Seung Tae Im, Kyung‐Mo Song, Tae‐Kyung Kim, Min Kyung Park, Jiyoon Cha, Yun‐Sang Choi, Min‐Cheol Kang
article en

Abstract

(AD) were evaluated using multiple in vitro models. The aqueous extracts of AD and PBS exhibited strong antioxidant activity in HepG2 hepatocytes and human dermal fibroblast (HDF) cells. Most extracts suppressed nitric oxide production in lipopolysaccharide-stimulated RAW 264.7 macrophages, indicating anti-inflammatory effects. In addition, all larval extracts inhibited β-hexosaminidase release in IgE/BSA-stimulated mast cells, suggesting anti-allergic potential. The protein-rich aqueous and ethanolic extracts showed relatively stronger angiotensin-converting enzyme (ACE) inhibitory activity, whereas polyphenol-rich ethanolic extracts more effectively reduced lipid accumulation in differentiated 3T3-L1 adipocytes. These findings highlight solvent-dependent functional activity profiles of edible insect larval extracts and support their potential as sustainable sources of bioactive ingredients.

Food Science & NutritionVol. 14(5)
Chonnam National University (KR), Sungshin Women's University (KR), Chungnam National University (KR), Gwangju Institute of Science and Technology (KR), Korea Food Research Institute (KR), Korea Basic Science Institute (KR)
Ministry of Agriculture, Food and Rural Affairs, Ministry of Science and ICT, South Korea
Responsible consumption and production
Openalex Percentile: Top 9%
Insect Utilization and Effects
DOIOpen Access PDFOpenAlex
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