Involvement of interaction between TRPM2 and IKCA1 in temperature-dependent movement and IL-1β production in mouse microglia
efflux, followed by cell shrinkage upon water efflux. In addition, mouse microglia exhibited temperature-dependent movement in vitro that was modulated by the TRPM2-IKCA1 interaction within the physiological body temperature range. This interaction was also found to be involved in cytokine production in microglia. Understanding how the TRPM2-IKCA1 interaction in microglia can promote cell movement and cytokine production could be valuable for developing new strategies for treatments of diseases involving TRPM2.
Authors
- Susumu Ohya (ORCID: https://orcid.org/0000-0002-5765-0667)
- Aykut Deveci (ORCID: https://orcid.org/0000-0002-9008-7685)
- Makiko Kashio (ORCID: https://orcid.org/0000-0001-6404-2339)
- Moe Iwata
- Sandra Derouiche
- Yuji Imaizumi
- Makoto Tominaga (ORCID: https://orcid.org/0000-0003-3111-3772)
- Lei Jing
Institutions
- National Institutes of Natural Sciences (JP)
- The Graduate University for Advanced Studies, SOKENDAI (JP)
- Nagoya City University (JP)
- Nagoya University Hospital (JP)
- Nagoya University (JP)
- Kumamoto University (JP)
Publication Details
- Journal
- The Journal of Physiological Sciences
- Published
- 2026-05-01
- DOI
- https://doi.org/10.1016/j.jphyss.2026.100077
- Primary Topic
- Ion Channels and Receptors
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Japan Society for the Promotion of Science