Electronic Circuit Design and Modeling of Biodegradable Mxene-Based Wireless Biosensor for Deep Wound Monitoring

One of the most significant challenges of medical care is the infection of postoperative wounds, and conventional visual examination often fails to detect it early. This research proposes the design of an innovative, passive wireless telemetry system for non-intrusive monitoring of the wound-healing process. The system integrates a biocompatible resonance circuit (LC) with a high-sensitivity piezoresistive sensor based on MXene (Ti3C2Tx). It operates within the standard industrial and medical (ISM) band at 13.56 MHz.The detection mechanism in the system is based on the principle of "impedance modulation" (Impedance Modulation), which arises from changes in the sensor's resistance under physiological tissue pressure. The system was modeled and simulated using the Proteus environment to evaluate its frequency response. The results showed a high dynamic range, as the system recorded a stable output voltage of 863 mV (-1.28 dB) during the recovery phase (Rs≈10KΩ), against a sharp decrease to 15 mV (-36.5 dB) during the inflammation phase (Rs≈100Ω), which effectively indicates the phenomenon of "signal breakdown." In addition, sensitivity analysis emphasized the importance of component compatibility, as an amplitude mismatch caused the resonance frequency to shift to 11.9 MHz. The proposed system can accurately distinguish between healthy and inflamed tissues.