Genotype distribution of human papillomavirus (HPV) types in oral gargle specimens among men living with HIV in Mexico, Brazil, and Puerto Rico: A cross-sectional study

OBJECTIVES: Assess the distribution of oral HPV genotypes and examine their associations with age and HIV-related factors among men living with HIV. METHODS: on oral gargles. Demographics and HIV-related characteristics were collected via questionnaires, and clinical assessments were conducted. ANOVA and chi-square tests assessed associations with age groups and HPV infection. RESULTS: Among 700 participants, oral HPV was detected in 27.9%, with HR-HPV detection at 11.0%. 4vHPV and 9vHPV types were detected in 4.9% and 8.9% participants, respectively. The most detected HR-HPV types were HPV 16 (2.4%), HPV 33 (2.0%), and HPV 52 (2.0%). No significant age-specific differences in oral HPV detected were observed. Higher detection rates of any HPV and HR-HPV were observed among participants with baseline CD4 counts below 200 cells/mm³ or a history of AIDS-defining conditions. CONCLUSIONS: Oral HPV genotyping in men with HIV reveals distinct oncogenic patterns, underscoring the need to monitor long-term OPSCC risk.

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Publication Details

Journal
Journal of Infection
Published
2026-05-01
DOI
https://doi.org/10.1016/j.jinf.2026.106751
Primary Topic
Head and Neck Cancer Studies
Type
article
Field-Weighted Citation Impact
0.00

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article

Genotype distribution of human papillomavirus (HPV) types in oral gargle specimens among men living with HIV in Mexico, Brazil, and Puerto Rico: A cross-sectional study

Anna Beltrame, Vikrant V. Sahasrabuddhe, Margaret G. House, Timothy Wilkin et al.
Journal of Infection
Head and Neck Cancer Studies
article

Genotype distribution of human papillomavirus (HPV) types in oral gargle specimens among men living with HIV in Mexico, Brazil, and Puerto Rico: A cross-sectional study

Anna Beltrame, Vikrant V. Sahasrabuddhe, Margaret G. House, Timothy Wilkin, Grant Ellsworth, Emma Brofsky, Wenyi Fan, Lenice Galan de Paula, Jorge Santana-Bagur, Kimberly Isaacs-Soriano, Julie Rathwell, Eduardo Lazcano-Ponce, Betania Allen-Leigh, Anna R. Giuliano, Alejandra J. Portillo-Romero, Luisa L. Villa, Roberto Carvalho da Silva, Caique Mello, Michael J. Schell
article en

Abstract

OBJECTIVES: Assess the distribution of oral HPV genotypes and examine their associations with age and HIV-related factors among men living with HIV. METHODS: on oral gargles. Demographics and HIV-related characteristics were collected via questionnaires, and clinical assessments were conducted. ANOVA and chi-square tests assessed associations with age groups and HPV infection. RESULTS: Among 700 participants, oral HPV was detected in 27.9%, with HR-HPV detection at 11.0%. 4vHPV and 9vHPV types were detected in 4.9% and 8.9% participants, respectively. The most detected HR-HPV types were HPV 16 (2.4%), HPV 33 (2.0%), and HPV 52 (2.0%). No significant age-specific differences in oral HPV detected were observed. Higher detection rates of any HPV and HR-HPV were observed among participants with baseline CD4 counts below 200 cells/mm³ or a history of AIDS-defining conditions. CONCLUSIONS: Oral HPV genotyping in men with HIV reveals distinct oncogenic patterns, underscoring the need to monitor long-term OPSCC risk.

Journal of InfectionVol. 92(6)
University of Puerto Rico System (PR), Cornell University (US), UC San Diego Health System (US), Moffitt Cancer Center (US), University of California San Diego (US), Instituto do Câncer do Estado de São Paulo (BR), National Institute of Public Health (KH), Centro de Referência em Informação Ambiental (BR), National Institute of Public Health (LA), Instituto Nacional de Salud Pública (MX), National Cancer Institute (US), University of Puerto Rico at Carolina (PR)
Division of Cancer Prevention, National Cancer Institute
Good health and well-being
Openalex Percentile: Top 10%
Head and Neck Cancer Studies
DOIOpen Access PDFOpenAlex
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