Efficient Total Synthesis of Densely Functionalized Natural Products by New Complexity-Generating Strategy

-diterpenoid alkaloid. In batrachotoxin synthesis, the intermolecular coupling of AB-ring and D-ring fragments was realized at sterically congested positions by utilizing a palladium/silver (Pd/Ag)-promoted Suzuki-Miyaura coupling reaction. In the synthesis of puberuline C, the 2 rings and 5 contiguous stereocenters were simultaneously constructed by a radical cascade reaction, increasing the complexity of the molecule in a single step.