Intraoperative Liposomal Bupivacaine Is Associated With Reduced Opioid Use and Enhanced Recovery After Total Knee Arthroplasty: A Multicenter Registry Study

Background: With an annual volume of total knee arthroplasties (TKAs) in the United States projected to exceed 1.5 million by 2050, optimizing perioperative pain control and facilitating early discharge remain clinical priorities. This study evaluated the effectiveness of liposomal bupivacaine (LB) vs conventional bupivacaine/ropivacaine in opioid-naïve patients undergoing primary TKA, comparing/contrasting: (1) pain score improvements, (2) opioid usages, (3) functional recoveries, and (4) hospital lengths of stay. Methods: < .05. Results: = .007). Conclusions: Use of LB is associated with improved pain control, reduced opioid use, and shorter lengths of stay following TKA. This study highlights LB's utility in facilitating early mobilization and advancing perioperative care.

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Publication Details

Journal
Arthroplasty Today
Published
2026-05-01
DOI
https://doi.org/10.1016/j.artd.2026.101968
Primary Topic
Anesthesia and Pain Management
Type
article
Field-Weighted Citation Impact
0.00

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article

Intraoperative Liposomal Bupivacaine Is Associated With Reduced Opioid Use and Enhanced Recovery After Total Knee Arthroplasty: A Multicenter Registry Study

Andrew I. Spitzer, William M. Mihalko, Adam Rivadeneyra, David Rogenmoser et al.
Arthroplasty Today
Anesthesia and Pain Management
article

Intraoperative Liposomal Bupivacaine Is Associated With Reduced Opioid Use and Enhanced Recovery After Total Knee Arthroplasty: A Multicenter Registry Study

Andrew I. Spitzer, William M. Mihalko, Adam Rivadeneyra, David Rogenmoser, Mary DiGiorgi, Jennifer H. Lin, Michael A. Mont, Mitchell K. Ng, Vinod Dasa, Joshua Urban, Andrew L. Concoff
article en

Abstract

Background: With an annual volume of total knee arthroplasties (TKAs) in the United States projected to exceed 1.5 million by 2050, optimizing perioperative pain control and facilitating early discharge remain clinical priorities. This study evaluated the effectiveness of liposomal bupivacaine (LB) vs conventional bupivacaine/ropivacaine in opioid-naïve patients undergoing primary TKA, comparing/contrasting: (1) pain score improvements, (2) opioid usages, (3) functional recoveries, and (4) hospital lengths of stay. Methods: < .05. Results: = .007). Conclusions: Use of LB is associated with improved pain control, reduced opioid use, and shorter lengths of stay following TKA. This study highlights LB's utility in facilitating early mobilization and advancing perioperative care.

Arthroplasty TodayVol. 39
Cedars-Sinai Medical Center (US), Maimonides Medical Center (US), Thomas Jefferson University Hospital (US), Sinai Hospital (US), Orthopaedic Center (US), Rothman Orthopaedics (US), Pacira (United States) (US), Orthopaedic Specialty Institute (US), Campbell Clinic (US), Louisiana State University Health Sciences Center New Orleans (US)
U.S. Department of Commerce, Campbell Foundation, 3M, Orthopaedic Research Society, American Association of Hip and Knee Surgeons, Pacira BioSciences, National Institutes of Health, U.S. Food and Drug Administration, Knee Society
Good health and well-being
Openalex Percentile: Top 14%
Anesthesia and Pain Management
DOIOpen Access PDFOpenAlex
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