The Chemical Constituents of <i>Euphorbia tibetica</i> and Their Bioactivities

In the phytochemical study of Euphorbia tibetica, one undescribed ring-opening secoiridoid ether terpenoid, named compound 1, along with 13 known compounds 2-14, was isolated. Their structures were elucidated by comprehensive spectroscopic analysis (HRESIMS, 1D, and 2D NMR) and comparison with published literature data. Biological research discovered that compounds 9 and 12 exhibited potent antichlamydial activity at 200 µM, while compounds 7 and 8 showed moderate activity against three different pathogenic fungi at 30 µg/mL. The results suggested that compounds 9 and 12 might be a promising class of therapeutic agents for chlamydial infections.