Defining a Midgestational Window for <i>In Utero</i> Genome Editing of the Fetal Murine Cortex
. Importantly, we show that edited cells span neural progenitors and differentiated neurons across the cortex and hippocampus. These results define a permissive midgestational window for prenatal genome editing, providing a platform for functional modeling of congenital CNS disorders and exploration of early therapeutic interventions with minimized peripheral exposure.
Authors
- Gerard Michael Coughlin (ORCID: https://orcid.org/0000-0003-0644-4721)
- Viviana Gradinaru (ORCID: https://orcid.org/0000-0001-5868-348X)
- Cameron Jackson
- Máté Borsos (ORCID: https://orcid.org/0000-0002-2801-8910)
- Nathan Appling (ORCID: https://orcid.org/0009-0007-9488-6621)
- Carrie R Jackson
Institutions
- California Institute of Technology (US)
- Howard Hughes Medical Institute (US)
Publication Details
- Journal
- bioRxiv (Cold Spring Harbor Laboratory)
- Published
- 2026-05-01
- DOI
- https://doi.org/10.64898/2026.04.28.721509
- Primary Topic
- CRISPR and Genetic Engineering
- Type
- article
- Field-Weighted Citation Impact
- 0.00