The TREM2 R47H variant is associated with liver-plasma-brain axis dyshomeostasis in the 5xFAD mouse model of Alzheimer’s disease
mice which impacts several key metabolic pathways involving lipids, cellular energy metabolism, and brain folate metabolism.
Authors
- Amrita K. Cheema (ORCID: https://orcid.org/0000-0003-4877-7583)
- Julio Avelar‐Barragan
- Andrea J. Tenner (ORCID: https://orcid.org/0000-0003-3000-024X)
- Gina Faraci (ORCID: https://orcid.org/0000-0003-2789-7383)
- Giedre Milinkeviciute (ORCID: https://orcid.org/0000-0003-2527-3892)
- Grant R. MacGregor (ORCID: https://orcid.org/0000-0001-7598-9501)
- Katrine Whiteson
- Mark Mapstone
- Frank M LaFerla
- Michael Vu
- Kim N Green
- Benjamin Goodfriend
- Joseph Bishop
- Jason Rothman
- Sage Dunham
Institutions
- University of California, Riverside (US)
- Georgetown University (US)
- University of California, Irvine (US)
Publication Details
- Journal
- Neurobiology of Aging
- Published
- 2026-04-30
- DOI
- https://doi.org/10.1016/j.neurobiolaging.2026.04.007
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institute on Aging
- National Cancer Institute