Sotorasib plus panitumumab and 5-fluorouracil in first-line treatment of patients with unresectable KRAS G12C mutated colorectal cancer unfit for a doublet/triplet chemotherapy: ENGIC 01 – PRODIGE 107 – FFCD 2306 – COLOSOTO trial
INTRODUCTION: 5-fluorouracil (5-FU) ± targeted therapy is a standard of care in frail/elderly patients with an unresectable colorectal adenocarcinoma (CRC) in first-line setting. Panitumumab plus sotorasib combination (KRAS G12C inhibitor) are promising in advanced line in KRAS G12C-mutated CRC. Here we assess the safety and efficacy of 5-FU combination with panitumumab and sotorasib as first-line treatment in frail/elderly patients with unresectable KRAS G12C-mutated CRC. METHODS: <50%), and 37 patients will need to be included. PERSPECTIVES: Treatment with 5-FU plus panitumumab and sotorasib could be a promising alternative to 5-FU ± targeted therapy in first-line setting in frail/elderly patients with unresectable KRAS G12C-mutated CRC.
Authors
- Claire Gallois (ORCID: https://orcid.org/0000-0003-2369-7341)
- Laura Delliponti
- Lisa Kochen
- Manon Pelkowski
- Alexej Ballhausen (ORCID: https://orcid.org/0000-0002-5470-4973)
- Thibault Mazard (ORCID: https://orcid.org/0000-0002-5644-9603)
- Meriem Guarssifi
- Matteo Landi (ORCID: https://orcid.org/0000-0003-3789-5840)
- Émilie Soularue (ORCID: https://orcid.org/0000-0003-3223-5720)
- Dominik Paul Modest (ORCID: https://orcid.org/0000-0002-6853-0599)
- R. Vidal Tocino (ORCID: https://orcid.org/0000-0002-0588-2001)
- Javier Sastre (ORCID: https://orcid.org/0000-0001-6538-0065)
- Adrien Grancher
- Ada Taravella (ORCID: https://orcid.org/0009-0000-2153-3867)
- Annabel Alig
- Karine Le Malicot
- Marta Beltran
- Chiara Cremolini
- David Tougeron
- Julien Taïeb
Institutions
- Peace Research Institute Frankfurt (DE)
- Inserm (FR)
- Université Paris Cité (FR)
- Hospital Clínico San Carlos (ES)
- Université de Poitiers (FR)
- Humboldt-Universität zu Berlin (DE)
- Institute Mutualiste Montsouris (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Hôpital Européen Georges-Pompidou (FR)
- Fédération Francophone de Cancérologie Digestive (FR)
- Institute of Clinical Cancer Research (DE)
- Instituto de Investigación Biomédica de Salamanca (ES)
- Institut de Recherche en Cancérologie de Montpellier (FR)
- Spanish Head & Neck Cancer Cooperative Group (ES)
- Azienda Ospedaliera Universitaria Pisana (IT)
- Université de Rouen Normandie (FR)
Publication Details
- Journal
- Digestive and Liver Disease
- Published
- 2026-05-01
- DOI
- https://doi.org/10.1016/j.dld.2026.04.009
- Primary Topic
- Colorectal Cancer Treatments and Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Amgen Foundation