Molecularly sculpted NIR-II nano-igniter converts local photothermal heat into systemic antitumor vaccination

T cells (≈ 70% activation), and suppression of Tregs (≈ 3%). No systemic toxicity or off-target pathology is observed. This study establishes a chemically tunable, metal-free PTA platform that synergizes thermal ablation with systemic anti-tumor immunity, providing a versatile scaffold for next-generation precision immuno-photothermal medicine.

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Publication Details

Journal
Journal of Nanobiotechnology
Published
2026-05-02
DOI
https://doi.org/10.1186/s12951-026-04361-x
Primary Topic
Nanoplatforms for cancer theranostics
Type
article
Field-Weighted Citation Impact
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article

Molecularly sculpted NIR-II nano-igniter converts local photothermal heat into systemic antitumor vaccination

Q Wang, Chunbai Xiang, M H Li, Y Sun et al.
Journal of Nanobiotechnology
Nanoplatforms for cancer theranostics
article

Molecularly sculpted NIR-II nano-igniter converts local photothermal heat into systemic antitumor vaccination

Q Wang, Chunbai Xiang, M H Li, Y Sun, Qihang Ding, Tingting Liu, Ruiping Zhang
article en

Abstract

T cells (≈ 70% activation), and suppression of Tregs (≈ 3%). No systemic toxicity or off-target pathology is observed. This study establishes a chemically tunable, metal-free PTA platform that synergizes thermal ablation with systemic anti-tumor immunity, providing a versatile scaffold for next-generation precision immuno-photothermal medicine.

Journal of Nanobiotechnology
Shanxi Medical University (CN), Korea University (KR), Chinese Academy of Sciences (CN), Huazhong Agricultural University (CN), Wuhan University (CN), Central China Normal University (CN), First Hospital of Shanxi Medical University (CN), Renmin Hospital of Wuhan University (CN), Shenzhen Institutes of Advanced Technology (CN)
Good health and well-being
Openalex Percentile: Top 14%
Nanoplatforms for cancer theranostics
DOIOpen Access PDFOpenAlex
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Molecularly sculpted NIR-II nano-igniter converts local photothermal heat into systemic antitumor vaccination — Q Wang, Chunbai Xiang, et al. · Journal of Nanobiotechnology (2026) | TGRS Research Map | TGRS