Association of Early Chemotherapy With Reduced In-Hospital Mortality and Complications in Acute Promyelocytic Leukemia: Insights From a Nationwide Cohort

Background/Aim: Prompt treatment in acute promyelocytic leukemia (APML) is critical due to high risk of early mortality. Early initiation of chemotherapy has been associated with favorable outcomes. The purpose of this study was to investigate differences in inpatient outcomes of APML based on time to chemotherapy initiation. Patients and Methods: -tests and Chi-squared tests. Results: 0.01 for all). Conclusion: Early chemotherapy was associated with lower rates of DIC, sepsis and mortality despite similar demographics and comorbidity burden in APML patients. These findings support immediate initiation of chemotherapy upon presentation.