Electrospray Regime Controls Sensitivity and Quantitative Performance in Micro- and Nano-Flow CE–ESI–MS
embryonic samples at single-cell-scale input, CJ significantly increased the number of detected metabolite features and improved recovery of functionally annotated protein groups. These results establish ESI regime as a controllable driver of sensitivity and quantitative performance in CE-ESI-MS and provide practical guidance for selecting ionization conditions for trace-limited analyses.
Authors
- Péter Nemes (ORCID: https://orcid.org/0000-0002-4704-4997)
- Laura Rodríguez (ORCID: https://orcid.org/0000-0002-6669-1962)
- Ryan M O'Neal
Institutions
- University of Maryland, College Park (US)
Publication Details
- Journal
- Analytical Chemistry
- Published
- 2026-05-02
- DOI
- https://doi.org/10.1021/acs.analchem.6c01323
- Primary Topic
- Mass Spectrometry Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Chan Zuckerberg Initiative
- National Institute of General Medical Sciences