ALS-FTD-linked CCNFS621G drives increased hippocampal astrocyte ramification and mitochondrial dysfunction and impairs motor neuron excitability
astrocytes to suppress repetitive neuronal firing suggests a critical astrocyte-driven non-cell autonomous mechanism that may contribute to an oligogenic role for CCNF in ALS/FTD pathogenesis.
Authors
- Rossana Rosa Porto (ORCID: https://orcid.org/0000-0002-7292-6756)
- Madilyn Coles
- Joanna Lui
- Claire H. Stevens (ORCID: https://orcid.org/0000-0003-4800-7466)
- Roger S. Chung (ORCID: https://orcid.org/0000-0002-9286-947X)
- Marco Morsch (ORCID: https://orcid.org/0000-0001-9484-8050)
- Rachelle Balez (ORCID: https://orcid.org/0000-0002-2787-7107)
- Rachel H. Tan (ORCID: https://orcid.org/0000-0002-0385-4090)
- Sonia Sanz Muñoz (ORCID: https://orcid.org/0000-0003-0970-3637)
- Leszek Lisowski (ORCID: https://orcid.org/0000-0002-4772-8651)
- Tracey Berg
- Lezanne Ooi (ORCID: https://orcid.org/0000-0001-9241-8268)
- Flora Cheng (ORCID: https://orcid.org/0000-0002-8070-5531)
- Gaétan Burgio (ORCID: https://orcid.org/0000-0002-7434-926X)
- Tim Karl (ORCID: https://orcid.org/0000-0001-9904-8482)
- Predrag Kalajdzic
- Liam Robinson
- Albert Lee
- Dzung Do-Ha
- Mauricio Castro Cabral-da-Silva
- Ian Blair
- Jamesha Subachandran
Institutions
- Australian National University (AU)
- Camden and Campbelltown Hospitals (AU)
- National Academy of Medicine (US)
- The University of Sydney (AU)
- Children's Medical Research Institute (AU)
- University of Wollongong (AU)
- Australian Cancer Research Foundation (AU)
- Western Sydney University (AU)
- Macquarie University (AU)
Publication Details
- Journal
- Journal of Neuroinflammation
- Published
- 2026-05-02
- DOI
- https://doi.org/10.1186/s12974-026-03827-x
- Primary Topic
- Amyotrophic Lateral Sclerosis Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Motor Neurone Disease Research Institute of Australia
- Australian Plant Phenomics Facility
- Australian Research Council
- National Health and Medical Research Council