ALS-FTD-linked CCNFS621G drives increased hippocampal astrocyte ramification and mitochondrial dysfunction and impairs motor neuron excitability

astrocytes to suppress repetitive neuronal firing suggests a critical astrocyte-driven non-cell autonomous mechanism that may contribute to an oligogenic role for CCNF in ALS/FTD pathogenesis.

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Publication Details

Journal
Journal of Neuroinflammation
Published
2026-05-02
DOI
https://doi.org/10.1186/s12974-026-03827-x
Primary Topic
Amyotrophic Lateral Sclerosis Research
Type
article
Field-Weighted Citation Impact
0.00

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article

ALS-FTD-linked CCNFS621G drives increased hippocampal astrocyte ramification and mitochondrial dysfunction and impairs motor neuron excitability

Rossana Rosa Porto, Madilyn Coles, Joanna Lui, Claire H. Stevens et al.
Journal of Neuroinflammation
Amyotrophic Lateral Sclerosis Research
article

ALS-FTD-linked CCNFS621G drives increased hippocampal astrocyte ramification and mitochondrial dysfunction and impairs motor neuron excitability

Rossana Rosa Porto, Madilyn Coles, Joanna Lui, Claire H. Stevens, Roger S. Chung, Marco Morsch, Rachelle Balez, Rachel H. Tan, Sonia Sanz Muñoz, Leszek Lisowski, Tracey Berg, Lezanne Ooi, Flora Cheng, Gaétan Burgio, Tim Karl, Predrag Kalajdzic, Liam Robinson, Albert Lee, Dzung Do-Ha, Mauricio Castro Cabral-da-Silva, Ian Blair, Jamesha Subachandran
article en

Abstract

astrocytes to suppress repetitive neuronal firing suggests a critical astrocyte-driven non-cell autonomous mechanism that may contribute to an oligogenic role for CCNF in ALS/FTD pathogenesis.

Journal of Neuroinflammation
Australian National University (AU), Camden and Campbelltown Hospitals (AU), National Academy of Medicine (US), The University of Sydney (AU), Children's Medical Research Institute (AU), University of Wollongong (AU), Australian Cancer Research Foundation (AU), Western Sydney University (AU), Macquarie University (AU)
Motor Neurone Disease Research Institute of Australia, Australian Plant Phenomics Facility, Australian Research Council, National Health and Medical Research Council
Openalex Percentile: Top 12%
Amyotrophic Lateral Sclerosis Research
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