The tryptophan prenyltransferase <scp>ComQ</scp> from <i>Bacillus subtilis</i> 168 can prenylate daptomycin at Trp1
, previously known to modify linear peptides, can also farnesylate cyclic peptides-establishing its potential as a versatile tool in the biosynthetic engineering of bioactive compounds.
Authors
- Oscar P. Kuipers (ORCID: https://orcid.org/0000-0001-5596-7735)
- Yan Xu (ORCID: https://orcid.org/0000-0002-3319-4695)
- Maximilian J L J Fürst
Institutions
- University of Groningen (NL)
- Dialyse Centrum Groningen (NL)
Publication Details
- Journal
- FEBS Journal
- Published
- 2026-05-02
- DOI
- https://doi.org/10.1111/febs.70578
- Primary Topic
- Microbial Natural Products and Biosynthesis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- China Scholarship Council