Proper localization of the SCA13-linked K+ channel in Purkinje neurons requires a microtubule-stabilizing protein
channels. In Purkinje neurons, shRNA-mediated MAP6 knockdown decreases somatodendritic levels of both Kv3.3 and Cav2.1 (associated with SCA6). Notably, expression of Mn1/2-GFP selectively reduces Kv3.3, but not Cav2.1, levels. Purkinje neuron burst firing is reduced in both conditions. These findings uncover a MAP6-dependent mechanism for targeting two key ion channels linked to SCAs.
Authors
- Chen Gu (ORCID: https://orcid.org/0000-0003-3052-4545)
- Peter Jukkola (ORCID: https://orcid.org/0000-0001-6076-1117)
- Jason C. Wester (ORCID: https://orcid.org/0000-0001-8434-9549)
- Annie Andrieux (ORCID: https://orcid.org/0000-0002-4022-6405)
- Christophe Bosc (ORCID: https://orcid.org/0000-0002-3195-6692)
- Sylvie Gory‐Fauré (ORCID: https://orcid.org/0000-0001-5743-8079)
- Nanditha Nalinakshan (ORCID: https://orcid.org/0000-0002-5140-3577)
- Alec H. Marshall
- Di Ma
Institutions
- Inserm (FR)
- Commissariat à l'Énergie Atomique et aux Énergies Alternatives (FR)
- CEA Grenoble (FR)
- Grenoble Institute of Neurosciences (FR)
- The Ohio State University (US)
- Université Grenoble Alpes (FR)
Publication Details
- Journal
- Neurobiology of Disease
- Published
- 2026-04-30
- DOI
- https://doi.org/10.1016/j.nbd.2026.107429
- Primary Topic
- Ion channel regulation and function
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institute of Neurological Disorders and Stroke